Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulationArticle Published on 2022-09-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition antibody Antigen C57BL/6 CD4 Complete conditions coronavirus COVID-19 demonstrated Diseases displaying dose effective hallmark highlight IgG immune response immunization in vitro in vivo Lipid-based nanoparticles mice modulated MPLA Nano-multilamellar vesicles promote Protein RBD Receptor binding domain reduced required responses Safe SARS-CoV-2 serum spike subunit Subunit vaccine T-cell Response T-cell responses toxic effect Vaccine vaccine. Vaccines Vesicle virus-neutralizing antibody [DOI] 10.1016/j.nano.2022.102595 PMC 바로가기
Consumption and ocurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A reviewReview article Published on 2022-07-012022-10-05 Journal: The Science of the total environment [Category] 바이오마커, [키워드] addition adjuvant Adverse reactions Analysis Anxiety bulimia Characteristics complex Concentration Consumption COVID-19 COVID-19 pandemic Critical Depression disease drugs Effect Environment future risk generate increase in indicated Laboratory mechanism Mental disorder Obsessive-compulsive disorder Occurrence Ocurrence Organisms pandemic persistence physicochemical characteristics physicochemical property serotonin reuptake inhibitor significantly SSRIs terrestrial toxic effect Treatment [DOI] 10.1016/j.scitotenv.2022.154656 [Article Type] Review article
Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19COVID-19의 주요 독성 인자인 Nsp1을 억제하는 용도 변경 약물의 시너지 상호 작용Article Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, 치료제, [키워드] C-terminal Combination Compound COVID-19 Cytopathic effect expressed functional inhibit inhibited Interaction lung cells Montelukast Multiple Mutation nsp1 Ponatinib Protein Repurposed drug reversed Rilpivirine SARS-CoV-2 genome significantly synergistic the SARS-CoV-2 genome toxic effect toxic effects treat Virtual screening virulence virulence factor was used [DOI] 10.1038/s41598-022-14194-x PMC 바로가기 [Article Type] Article
Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeriDanio rerio 및 Allivibrio fischeri에 광유도 공정으로 처리된 로피나비르 및 리토나비르 함유 용수 및 폐수의 독성 공개Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] 치료제, [키워드] Affect affecting antiviral drug antiviral drugs Bacteria Behavior Chronic toxicity Concentration Contact contact with coronavirus disease Coronavirus disease 2019 COVID-19 Danio drug Ecotoxicity edema Efficiency form hospital Impact increase in indicate Inflammation Lopinavir LOPINAVIR AND RITONAVIR Organisms oxidative stress oxygen parameter Photocatalysis Photolysis physicochemical plants predicted problem protocols reduce Ritonavir Ritonavir. shortening significantly survival tail toxic effect Toxicity treated Treatment wastewater water zebrafish [DOI] 10.1016/j.scitotenv.2022.153967 PMC 바로가기 [Article Type] Article
Benzo[ a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity벤조[a]피렌-환경 발생, 인체 노출 및 독성 메커니즘Review Published on 2022-06-062022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] aromatic hydrocarbon association benzo[a]pyrene carcinogenic carcinogenicity cause cigarette smoke concerning COVID-19 pandemic cytochrome P450 determine DNA epoxy Evidence exhibit exposure exposure to expressed facilitate genotoxicity Human impairment involved mechanism metabolism multiplication Mutation neurotoxic Occurrence organism P450 polycyclic polycyclic aromatic hydrocarbons. polymorphism pyrene receptor sensitivity Soil Surface water teratogenic toxic effect toxic effects Toxicity turn viruses water widespread xenobiotics [DOI] 10.3390/ijms23116348 PMC 바로가기 [Article Type] Review
The associations between air pollutant exposure and neutralizing antibody titers of an inactivated SARS-CoV-2 vaccine비활성화된 SARS-CoV-2 백신의 대기 오염 물질 노출과 중화 항체 역가 사이의 연관성Article Published on 2022-02-012022-09-12 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Administered Affect Air pollutants Air pollution Antibody titer applied association calculate China chronic chronic inflammation collected Combined Combined toxic effects complex conducted CoronaVac COVID-19 epidemic Critical dose Efficacy elevated eligible environmental factor exposure group expression geometric healthcare worker Healthcare workers identify Immunity inactivated Inactivated SARS-CoV-2 vaccine inhibit knowledge median monocyte NAb titers neutralizing antibody Neutralizing antibody titer Neutralizing antibody titer. observation participant plasma plasma NAb titer prevalence of COVID-19 recruited risk factor SARS-CoV-2 SARS-CoV-2 vaccine the mean the SARS-CoV-2 toxic effect two group vaccination Vaccine Vero Cell White blood cell [DOI] 10.1007/s11356-021-16786-y PMC 바로가기 [Article Type] Article
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19COVID-19 치료를 위한 SARS-CoV-2의 스파이크 단백질을 표적으로 하는 이중특이성 CAR-T 세포에서 유래한 나노소포Research Published on 2021-11-252022-09-10 Journal: Journal of Nanobiotechnology [Category] MERS, 진단, 치료제, [키워드] ADE Adverse drug reactions Antibody-dependent enhancement Antibody-mediated neutralization Antiviral antiviral drug antiviral drugs binding ability CAR-T CAR-T cell caused Cell co-expression COVID-19 COVID-19 pandemic CR3022 develop dilemma drug drugs effective Effects epitope Epitopes Express facilitate Fc fragment help incidence Infection inhibiting lack nanovesicles neutralization neutralize Neutralizing antibodies neutralizing antibody overexpressing present Prevent problem Pseudotyped virus reduce reducing Remdesivir Result SARS-CoV-2 SARS-CoV-2 spike protein scFv selective single antibody Spike protein spike protein of SARS-CoV-2 supplementary material T cells Targeted delivery the spike protein Therapeutic approach toxic effect treat treating COVID-19 Treatment treatment of COVID-19 variable Viral viral infection viral replication Viral resistance virus [DOI] 10.1186/s12951-021-01148-0 PMC 바로가기 [Article Type] Research
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells인간 PSC 유래 심근세포 및 1차 내피 세포에서 항고혈압 약물 치료 및 SARS-CoV-2 감염에 대한 감수성Article Published on 2021-10-122022-09-11 Journal: Stem Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACEi acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter angiotensin angiotensin receptor blocker angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Antihypertensive drug antihypertensive medication ARB Cell cell type Coronavirus-2 COVID-19 drug treatment endothelial Endothelial cell endothelial cells Enzyme inhibitor heart hPSC-derived cardiomyocytes Immunity interferon involved Lisinopril losartan MAPK medications membrane-bound mitogen mitogen-activated protein kinase modulate multicenter trials Necrosis NF-κB not affect nuclear pathogenicity Pathways Protein protein coding gene protein coding genes protein kinase receptor receptor blocker RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signaling pathways significant difference significant differences stem cells stem cells. susceptibility therapy TNF toxic effect toxic effects Transcriptome transcriptome change transcriptome changes Treatment Tumor tumor necrosis tumor necrosis factor [DOI] 10.1016/j.stemcr.2021.08.018 PMC 바로가기 [Article Type] Article
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial CellsSARS-COV-2의 스파이크 단백질은 뇌 내피 세포에서 분자 전달 및 대사 기능에서 병리학 적 변화를 유도한다.Article Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 BBB Blood–brain barrier Brain cause change changes in component components coronavirus coronavirus disease COVID-19 delivery dextran drastic Effect Endothelial cell endothelial cells enzyme Express function functional host cells induce infected with SARS-CoV-2 infecting infectious agent infectious agents marker mechanism metabolic metabolic function metabolism mitochondrial molecular neurological sign neurological signs Neurological symptom Neurological symptoms pathogenic pathological pathological mechanism permeability physiological RBD recent receptor Receptor-binding domain respiratory S1 domain SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown spike Spike protein the receptor-binding domain toxic effect toxic effects Transferrin Treatment trimer was increased [DOI] 10.3390/v13102021 PMC 바로가기 [Article Type] Article